VDR is a Virtual Data Room that provides secure, reliable access to confidential documents for business transactions. VDRs are utilized for due diligence during mergers and acquisitions and they help companies organize and share important documents with investors and other stakeholders. VDRs can also be used to store and manage contracts, invoices, and other legal documents like litigation and estate planning.
Members should examine their current procedures and equipment fitted to their vessels with a VDR/S-VDR installed. It is recommended to upgrade and replace any that are outdated or do not meet the minimum safety standards.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the production of proteins involved in a range of physiologic processes.
The VDR is present in neurons as well as a subset of glial cells, which form part of the brain. In primary hippocampal cultures of rodents, VDR immunoreactivity was detected in oligodendrocytes. The VDR is also found in human neuroblastoma and astrocytes. Treatment of HL-60 find here myeloblast leukemia cells with 1,25(OH)2D3 caused monocyte-like differentiation and increased VDR protein levels. This effect was reversible by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.
