Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological aim and pharmacology regarding curcumin
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin ‘s the significant https://kissbrides.com/sv/guyanes-kvinnor/ element of the new red-colored dye away from turmeric, an enthusiastic Indian spice that is extracted from the fresh new rhizome of your tropical bush Curcuma longa, and that belongs to the Zingiberaceae family unit members. Within this section, we discuss the pharmacological activities away from curcumin and mention the unit angles for these activities. I up coming comment the fresh new proven and you can possible health-related uses from curcumin. Curcumin is well known typically since the a therapeutic representative, however, the procedure regarding step is in depth. The latest pharmacological outcomes of curcumin seem to be the consequence of an excellent synergism from channels out of poor biochemical relationships having several biological needs when you look at the interrelated signaling paths. This type of needs become enzymes for example cyclooxygenase, lipoxygenase and you can healthy protein kinases, and you may transcription issues including NF-?B, STAT and you will Nrf2. Modulation of them molecules has an effect on downstream affectors that produce new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial affairs of curcumin. These outcomes was checked from inside the systematic products regarding curcumin getting soreness and inflammatory sickness, cancer, Alzheimer state, aerobic ailment, and you will diabetes. The fresh samples purchased variable doses regarding curcuminwith some other wavelengths and you will duration, to the standard completion one high dosage out-of curcumin at the level of grams have to see therapeutic consequences. Find out more
Curcumin: Synthesis, Growing Character from inside the Pain Administration and Health Ramifications
Publication Part Types of bush-derived pharmaceuticals which have end up being the focus regarding continuous and you can exponential research and you will invention interest features, up to now, already been some scarce. After a long period, the final two decades have been characterized by an excellent 100-fold rise in just how many medical articles penned a-year you to definitely try out of benefits for the entry to curcumin inside biomedicine. Find out more
Design, synthesis and you may physical facts away from curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many possible pharmacological outcomes and may provides therapeutic apps in many disease claims, as the discussed in more detail in the previous part. not, the potential health-related efficacy off curcumin is bound by their physicochemical attributes away from poor water solubility and imbalance, and that end up in reasonable bioavailability. Prodrugs regarding curcumin provide a way to improvement of your own biopharmaceutical and you may pharmacokinetic attributes, and may even enable it to be exploitation of pharmacological negative effects of curcumin. Within this section, we earliest opinion new physicochemical and you may pharmacokinetics out of curcumin. I then describe the style of curcumin prodrugs having enhanced water solubility and you may enhanced chemical compounds balance that can be converted back again to free curcumin through to bioactivation in vivo. I highlight recent profits in this region, which have a focus on the structure, synthesis and you can research out of prodrugs according to promoieties including proteins, fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric content particularly hyaluronic acidic and polyethylene glycol. That it chapter contains the basis for optimization of your own physicochemical and you will biopharmaceutical features and the biological items of curcumin prodrugs, to your purpose having fun with of these curcumin types within the scientific apps. Find out more
